中文名稱

ISG15 E1 蛋白(人)

英文名字

ISG15 E1 protein(human)

供應商

Viva Bioscience

產(chǎn)品貨號

VB2650-25

產(chǎn)品報價

￥3625/25ug

產(chǎn)品說明書

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背景資料

ISG15 is an interferon (IFN)-alpha/beta-induced ubiquitin-like protein that is conjugated to cellular proteins during innate immune responses to bacterial and viral infections, including HIV.

Conjugation of ISG15 to cellular proteins occurs in a parallel but distinct mechanism to that of ubiquitin. The E1 activating enzyme for ISG15, is a single-subunit, ATP dependent enzyme, also known as Ube1L showing a high level of similarity to the E1 activating enzyme for ubiquitin at the protein level. However, this protein does not form a conjugate with ubiquitin, indicating that Ube1L is an E1 enzyme for the ISG15 conjugation system (ISGylation).

UbcH8, a member of the ubiquitin E2-conjugating enzyme family, has been identified as a major E2 enzyme for the ISGylation pathway, interacting with Ube1L to facilitate target protein ISGylation. As for ISG15 and Ube1L, UbcH8 expression is induced by IFN. A number of target proteins conjugated with ISG15 have been identified along with HERC5, an IFN-induced HECT domain-containing E3 protein ligase, shown to be responsible for mediation of cellular protein ISGylation, and itself a target for modification by ISG15.

序列

P41226

來源宿主

溶解建議

1 mg/mL

保存建議

其他

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注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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