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中文名稱

GABARAPL2 多克隆抗體

英文名字
GABARAPL2 polyclonal antibody
供應商
Viva Bioscience
產品貨號
VB3132-50
產品報價
￥3750/50ug
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背景資料
Key autophagy protein. Essential for autophagosome biogenesis, particularly elongation and closure. Required for cargo/substrate selection in some forms of selective autophagy

Background:
Autophagy involves concerted action of more than 20 specific autophagy (ATG) proteins that mediate the formation of a double-membrane vesicle, the autophagosome, which engulfs its substrates and delivers them to the lysosome for degradation. In many cases control of substrate selectivity is mediated by ubiquitin modification.

The autophagy pathway in mammalian cells is negatively regulated by mammalian target of rapamycin (mTor), inactivation of which leads to initiation of phagophore assembly. Formation and expansion of the pre-autophagosomal structure in yeast requires the attachment of the ubiquitin-like protein ATG8 via its C-terminal glycine to the amino group of phosphatidylethanolamine (PE), enabling its anchoring to the isolation membrane of the autophagosome. In mammals, Atg8 is represented by at least six orthologs that fall into two subgroups, LC3- and GABARAP-like proteins and the free and PE linked versions of these proteins are often referred to as LC3-I and LC3-II respectively.
應用類型
免疫原
Recombinant human GABARAPL2 protein fragment
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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