PDGFRA ELISA試劑盒 (Rat)-PDGFRA ELISA Kit (Rat)代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: PDGFRA ELISA試劑盒 (Rat)

英文名字: PDGFRA ELISA Kit (Rat)

供應(yīng)商: Aviva Systems Biology

產(chǎn)品貨號(hào): aviva-OKCD02766-96W

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/96Wells

產(chǎn)品說明書: 點(diǎn)擊查看

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity).

產(chǎn)品描述: 該P(yáng)DGFRA ELISA Kit (Rat)的產(chǎn)品描述請(qǐng)參考該產(chǎn)品的說明書

產(chǎn)品特點(diǎn): ELISA試劑盒

保存建議: 2°C to 8°C|-20°C

其他: Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國北京設(shè)有辦公室，專注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質(zhì)和定制服務(wù)。Aviva Systems Biology生產(chǎn)了24,000種經(jīng)過驗(yàn)證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實(shí)驗(yàn)室服務(wù)包括蛋白表達(dá)和純化、抗體開發(fā)，以及ELISA的開發(fā)、驗(yàn)證和生產(chǎn)。Aviva Systems Biology為與獨(dú)特物種和靶標(biāo)相關(guān)的研究提供獨(dú)特工具，研究領(lǐng)域包括轉(zhuǎn)錄因子、癌癥、心血管、細(xì)胞生物學(xué)、DNA損傷和修復(fù)、表觀遺傳學(xué)、信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞分化、干細(xì)胞生物學(xué)等等。