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ELISA試劑盒
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中文名稱(chēng)

HMGB1 ELISA試劑盒 (Rat)

英文名字
HMGB1 ELISA Kit (Rat)
供應(yīng)商
Aviva Systems Biology
產(chǎn)品貨號(hào)
aviva-OKCD04073-96W
產(chǎn)品報(bào)價(jià)
￥詢(xún)價(jià)/96Wells
產(chǎn)品說(shuō)明書(shū)
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銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線(xiàn)支付寶及網(wǎng)銀支付，或直接與我們電話(huà)聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。
產(chǎn)品新聞
背景資料
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
產(chǎn)品描述
該HMGB1 ELISA Kit (Rat)的產(chǎn)品描述請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)
產(chǎn)品特點(diǎn)
ELISA試劑盒
保存建議
2°C to 8°C|-20°C
其他
Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國(guó)北京設(shè)有辦公室，專(zhuān)注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質(zhì)和定制服務(wù)。Aviva Systems Biology生產(chǎn)了24,000種經(jīng)過(guò)驗(yàn)證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實(shí)驗(yàn)室服務(wù)包括蛋白表達(dá)和純化、抗體開(kāi)發(fā)，以及ELISA的開(kāi)發(fā)、驗(yàn)證和生產(chǎn)。Aviva Systems Biology為與獨(dú)特物種和靶標(biāo)相關(guān)的研究提供獨(dú)特工具，研究領(lǐng)域包括轉(zhuǎn)錄因子、癌癥、心血管、細(xì)胞生物學(xué)、DNA損傷和修復(fù)、表觀遺傳學(xué)、信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞分化、干細(xì)胞生物學(xué)等等。
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