日韩免费视频中文在线观看-国产成人在线视频一区二区三区-天天做天天爱天天大爽-欧美α片无限看在线观看免费-日本肥熟老熟妇15p-日本中文字幕三级在线视频-成人不卡视频在线观看-日韩一区二区三区无码人妻视频-青青草绿色视频在线观看

歡迎您訪(fǎng)問(wèn)武漢艾美捷科技有限公司官方網(wǎng)站！
站點(diǎn)地圖 服務(wù)熱線(xiàn)：400-6800-868
  • 產(chǎn)品
  • 文章

PRODUCT CENTER

ELISA試劑盒
產(chǎn)品中心

當(dāng)前位置：首頁(yè) > 產(chǎn)品中心 > 免疫學(xué)產(chǎn)品 > ELISA試劑盒

中文名稱(chēng)

LEP ELISA試劑盒 (Rat)

英文名字
LEP ELISA Kit (Rat)
供應(yīng)商
Aviva Systems Biology
產(chǎn)品貨號(hào)
aviva-OKCD05885-96W
產(chǎn)品報(bào)價(jià)
￥詢(xún)價(jià)/96Wells
產(chǎn)品說(shuō)明書(shū)
點(diǎn)擊查看
購(gòu)買(mǎi)方式
銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線(xiàn)支付寶及網(wǎng)銀支付，或直接與我們電話(huà)聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。
產(chǎn)品新聞
背景資料
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity) (PubMed:11677594). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:11460888, PubMed:10482243, PubMed:9003024, PubMed:11677594). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity) (PubMed:10482243, PubMed:9003024). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (By similarity). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (Probable). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity).
產(chǎn)品描述
該LEP ELISA Kit (Rat)的產(chǎn)品描述請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)
產(chǎn)品特點(diǎn)
ELISA試劑盒
保存建議
2°C to 8°C|-20°C
其他
Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國(guó)北京設(shè)有辦公室，專(zhuān)注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質(zhì)和定制服務(wù)。Aviva Systems Biology生產(chǎn)了24,000種經(jīng)過(guò)驗(yàn)證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實(shí)驗(yàn)室服務(wù)包括蛋白表達(dá)和純化、抗體開(kāi)發(fā)，以及ELISA的開(kāi)發(fā)、驗(yàn)證和生產(chǎn)。Aviva Systems Biology為與獨(dú)特物種和靶標(biāo)相關(guān)的研究提供獨(dú)特工具，研究領(lǐng)域包括轉(zhuǎn)錄因子、癌癥、心血管、細(xì)胞生物學(xué)、DNA損傷和修復(fù)、表觀(guān)遺傳學(xué)、信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞分化、干細(xì)胞生物學(xué)等等。
注意
該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠(chǎng)家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。
在線(xiàn)留言
產(chǎn)品分類(lèi)
特色產(chǎn)品 MORE
最近促銷(xiāo) MORE
  • 高品質(zhì)保障 成熟的生產(chǎn)研發(fā)技術(shù)
  • 高性?xún)r(jià)比 價(jià)宜質(zhì)優(yōu)，性?xún)r(jià)比高
  • 高效省心 從購(gòu)買(mǎi)到使用，放心無(wú)憂(yōu)
  • 安全運(yùn)輸 完善的保護(hù)措施安全運(yùn)輸

微信掃碼在線(xiàn)客服

微信咨詢(xún)

全國(guó)免費(fèi)技術(shù)支持

400-6800-868

在線(xiàn)客服