Recombinant rat Cellular tumor antigen p53 protein-Recombinant rat Cellular tumor antigen p53 protein代理/參數(shù)/廠家-重組蛋白-艾美捷科技有限公司

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背景資料: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.

來源宿主: 該Recombinant rat Cellular tumor antigen p53 protein的來源宿主請參考該產(chǎn)品的說明書

溶解建議: 該Recombinant rat Cellular tumor antigen p53 protein的溶解建議請參考該產(chǎn)品的說明書

保存建議: 該Recombinant rat Cellular tumor antigen p53 protein的保存建議請參考該產(chǎn)品的說明書

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