中文名稱(chēng)

Recombinant rat Cellular tumor antigen p53 protein

英文名字

Recombinant rat Cellular tumor antigen p53 protein

供應(yīng)商

Aviva Systems Biology

產(chǎn)品貨號(hào)

aviva-OPCA01075-20UG

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/20ug

產(chǎn)品說(shuō)明書(shū)

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產(chǎn)品新聞

背景資料

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.

序列

該Recombinant rat Cellular tumor antigen p53 protein的序列請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)

來(lái)源宿主

該Recombinant rat Cellular tumor antigen p53 protein的來(lái)源宿主請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)

溶解建議

該Recombinant rat Cellular tumor antigen p53 protein的溶解建議請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)

保存建議

該Recombinant rat Cellular tumor antigen p53 protein的保存建議請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)

其他

Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國(guó)北京設(shè)有辦公室，專(zhuān)注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質(zhì)和定制服務(wù)。Aviva Systems Biology生產(chǎn)了24,000種經(jīng)過(guò)驗(yàn)證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實(shí)驗(yàn)室服務(wù)包括蛋白表達(dá)和純化、抗體開(kāi)發(fā)，以及ELISA的開(kāi)發(fā)、驗(yàn)證和生產(chǎn)。Aviva Systems Biology為與獨(dú)特物種和靶標(biāo)相關(guān)的研究提供獨(dú)特工具，研究領(lǐng)域包括轉(zhuǎn)錄因子、癌癥、心血管、細(xì)胞生物學(xué)、DNA損傷和修復(fù)、表觀遺傳學(xué)、信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞分化、干細(xì)胞生物學(xué)等等。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

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