Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
序列
該DPP4 Recombinant Protein (Rat)的序列請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)
來(lái)源宿主
該DPP4 Recombinant Protein (Rat)的來(lái)源宿主請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)
溶解建議
該DPP4 Recombinant Protein (Rat)的溶解建議請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)
保存建議
該DPP4 Recombinant Protein (Rat)的保存建議請(qǐng)參考該產(chǎn)品的說(shuō)明書(shū)
其他
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