中文名稱

TLR4 Recombinant Protein (Rat)

英文名字

TLR4 Recombinant Protein (Rat)

供應(yīng)商

Aviva Systems Biology

產(chǎn)品貨號

aviva-OPCA05365-100UG

產(chǎn)品報價

￥詢價/100ug

產(chǎn)品說明書

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購買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).

序列

該TLR4 Recombinant Protein (Rat)的序列請參考該產(chǎn)品的說明書

來源宿主

該TLR4 Recombinant Protein (Rat)的來源宿主請參考該產(chǎn)品的說明書

溶解建議

該TLR4 Recombinant Protein (Rat)的溶解建議請參考該產(chǎn)品的說明書

保存建議

該TLR4 Recombinant Protein (Rat)的保存建議請參考該產(chǎn)品的說明書

其他

Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國北京設(shè)有辦公室，專注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質(zhì)和定制服務(wù)。Aviva Systems Biology生產(chǎn)了24,000種經(jīng)過驗證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實驗室服務(wù)包括蛋白表達和純化、抗體開發(fā)，以及ELISA的開發(fā)、驗證和生產(chǎn)。Aviva Systems Biology為與獨特物種和靶標(biāo)相關(guān)的研究提供獨特工具，研究領(lǐng)域包括轉(zhuǎn)錄因子、癌癥、心血管、細胞生物學(xué)、DNA損傷和修復(fù)、表觀遺傳學(xué)、信號轉(zhuǎn)導(dǎo)、細胞分化、干細胞生物學(xué)等等。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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