中文名稱

干細(xì)胞因子/ c-Kit抑制劑| c-Kit抑制劑II;?4-（1,1-二甲基乙基）-N- [4-（1H-咪唑-1-基）苯基]-苯磺酰胺

英文名字

Stem-Cell Factor/c-Kit Inhibitor|c-Kit Inhibitor II; 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-benzenesulfonamide

供應(yīng)商

Cayman Chemical

產(chǎn)品貨號(hào)

15781-1

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/1mg

產(chǎn)品說明書

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購買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

The receptor tyrosine kinase c-kit, activated by its ligand stem-cell factor (SCF), modulates diverse cellular processes, including cell proliferation, differentiation, and survival.{24624,20180} ISCK03 is a cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 μM.{25884} These concentrations also prevent SCF-mediated downstream phosphorylation of p44/p42 ERK but does not prevent phosphorylation of p44/p42 ERK induced by hepatocyte growth factor.{25884} Oral administration of ISCK03 in mice induces hair depigmentation, whereas topical application decreases epidermal melanin in guinea pig skin darkened by UV irradiation.{25884} ISCK03 has also been used to elucidate the role of SCF/c-kit signaling in cell viability, radiation-induced angiogenesis, and melanocortin receptor action.{25885,25887,25886}

產(chǎn)品描述

A cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 μM; prevents SCF-mediated downstream phosphorylation of p44/p42 ERK

產(chǎn)品形式

A crystalline solid

保存建議

建議您在收到Cayman Chemical品牌的ISCK03 (1 mg)產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

Cayman Chemical向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產(chǎn)品以及客戶訂制化服務(wù).

注意

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