N-乙酰基-D-赤型鞘氨醇-N-Acetyl-D-erythro-sphingosine代理/參數(shù)/廠家-標(biāo)準(zhǔn)品（生化）-艾美捷科技有限公司

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中文名稱: N-乙酰基-D-赤型鞘氨醇

英文名字: N-Acetyl-D-erythro-sphingosine

供應(yīng)商: Matreya

產(chǎn)品貨號(hào): 1901-10

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/10mg

產(chǎn)品說(shuō)明書(shū): 點(diǎn)擊查看

購(gòu)買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金,在線支付寶及網(wǎng)銀支付,或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料: This product contains a short-chain fatty acid and enters easily into cells where it is biologically active and has been shown to induce downregulation of Bcl-2 protein, inhibiting cell proliferation and inducing apoptosis.1 N-Acetyl-sphingosine demonstrates many of the biological activities associated with ceramides that contain long-chain fatty acids. However, it has also been found that N-acetyl-sphingosine may inhibit neutrophil superoxide release,2 stimulation of DNA synthesis, and phospholipase D activity. N-acetyl-sphingosine is different from sphingosine as seen by its inability to inhibit protein kinase C or cause calcium release. Ceramide functions as a precursor in the synthesis of sphingomyelin, glycosphingolipids, and of free sphingosine and fatty acids. The sphingosine can be phosphorylated to form sphingosine-1-phosphate. Two of ceramide’s metabolites, sphingosine-1-phosphate and glucosylceramide, produce cell proliferation and other cellular functions.2 Ceramide exerts numerous biological effects, including induction of cell maturation, cell cycle arrest, terminal cell differentiation, cell senescence, and cell death.3 Because of these effects ceramide has been investigated for its use in cancer treatment and many potential approaches to cancer therapy have been presented.4 Other effects include producing reactive oxygen in mitochondria (followed by apoptosis) and stimulating phosphorylation of certain proteins (especially mitogen activated protein). It also stimulates some protein phosphatases (especially protein phosphatase 2A) making it an important controller of protein activity. 2-hydroxy fatty acid ceramides are especially abundant in nervous and epidermal cells and are important for the permeability barrier function of epidermis and the lipid organization in membranes. The 2-hydroxylation is catalyzed by fatty acid 2-hydroxylase (FA2H or fatty acid alpha-hydroxylase).

產(chǎn)品描述: N-C2:0-D-erythro-Ceramide

產(chǎn)品形式: 該N-乙酰基-D-赤型鞘氨醇產(chǎn)品為固體形式

保存建議: 對(duì)于本產(chǎn)品，我們推薦使用-20℃藍(lán)冰低溫進(jìn)行運(yùn)輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說(shuō)明請(qǐng)參考本品說(shuō)明書(shū)。

其他: Matreya LLC是一家脂質(zhì)生化公司，致力于開(kāi)發(fā)和制造高質(zhì)量的脂質(zhì)和生物化學(xué)品。Matreya在化學(xué)合成以及天然產(chǎn)物提取和純化方面經(jīng)驗(yàn)豐富，生產(chǎn)出的產(chǎn)品具有最佳純度。 Matreya產(chǎn)品線包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和維生素E異構(gòu)體（生育酚和生育三烯酚）。專長(zhǎng)是生產(chǎn)高純度鞘氨醇、神經(jīng)酰胺、硫酸酯、神經(jīng)節(jié)苷脂、酶抑制劑、生育酚和生育三烯酚。是全球提供脂質(zhì)產(chǎn)品最全的供應(yīng)商之一。產(chǎn)品涉及生物化學(xué)、制藥、微生物學(xué)、食品和農(nóng)業(yè)等研究領(lǐng)域。