N-糖化的葡萄糖基鞘氨醇-N-Glycinated glucosylsphingosine代理/參數(shù)/廠家-標(biāo)準(zhǔn)品（生化）-艾美捷科技有限公司

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中文名稱: N-糖化的葡萄糖基鞘氨醇

英文名字: N-Glycinated glucosylsphingosine

供應(yīng)商: Matreya

產(chǎn)品貨號(hào): 2089-1

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/1mg

產(chǎn)品說明書: 點(diǎn)擊查看

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背景資料: N-Glycinated glucosylsphingosine is an analogue of the important biomolecule glucosylsphingosine. It is ideal for use as an internal standard in the extraction and mass spectrometry analysis of glucosylsphingosine from natural samples.(1) The free amine group gives this product very similar physical characteristics to the natural glycolipid while the glycine adds an additional 57 units to the molecule making it easy to detect by MS. Glucosylceramide and glucosylsphingosine are important biological species that are the precursors for many complex glycosphingolipids. These lipids are involved in critical cellular functions such as cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. One of the most important roles of glucosylsphingosine is as a biomarker for the lysosomal storage disorder Gaucher disease. Gaucher disease is characterized by an accumulation of glucocerebroside due to a deficiency in the enzyme glucocerebrosidase and it has now been found that glucosylsphingosine also accumulates in this disease.(2) This accumulation of glucopsychosine contributes to neuronal dysfunction and destruction in patients with neuronopathic Gaucher disease(3) and it has been found to be a potent inhibitor of glucocerebrosidase. At least some instances of Gaucher disease also have a deficiency in the activity of glucosylsphingosine beta-glucosidase, the enzyme responsible for cleaving off the glucose of glucopsychosine and glucocerebroside. Like glucocerebroside and galactocerebroside, glucosylsphingosine can increase Ca2 + mobilization from intracellular stores although it uses a different mechanism.(4)

產(chǎn)品描述: N-Glycinated 1-beta-D-lyso-glucosylceramide|N-Glycine glucopsychosine

產(chǎn)品形式: 該N-糖化的葡萄糖基鞘氨醇產(chǎn)品為固體形式

保存建議: 對(duì)于本產(chǎn)品，我們推薦使用-20℃藍(lán)冰低溫進(jìn)行運(yùn)輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說明請(qǐng)參考本品說明書。

其他: Matreya LLC是一家脂質(zhì)生化公司，致力于開發(fā)和制造高質(zhì)量的脂質(zhì)和生物化學(xué)品。Matreya在化學(xué)合成以及天然產(chǎn)物提取和純化方面經(jīng)驗(yàn)豐富，生產(chǎn)出的產(chǎn)品具有最佳純度。 Matreya產(chǎn)品線包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和維生素E異構(gòu)體（生育酚和生育三烯酚）。專長是生產(chǎn)高純度鞘氨醇、神經(jīng)酰胺、硫酸酯、神經(jīng)節(jié)苷脂、酶抑制劑、生育酚和生育三烯酚。是全球提供脂質(zhì)產(chǎn)品最全的供應(yīng)商之一。產(chǎn)品涉及生物化學(xué)、制藥、微生物學(xué)、食品和農(nóng)業(yè)等研究領(lǐng)域。