Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of the HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.
產(chǎn)品描述
A potent, reversible inhibitor of HDAC (IC50 = 70 mM)
產(chǎn)品形式
A crystalline solid
保存建議
建議您在收到Cayman Chemical品牌的Trichostatin A (1 mg)產(chǎn)品后置于-20度保存,產(chǎn)品有效期為730天.