dPEG? N-SATA(S-乙酰基-dPEG? N-NHS酯)-1000 mg-dPEG??-SATA (S-acetyl-dPEG??-NHS ester)-1000 mg代理/參數(shù)/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: dPEG? N-SATA(S-乙酰基-dPEG? N-NHS酯)-1000 mg

英文名字: dPEG??-SATA (S-acetyl-dPEG??-NHS ester)-1000 mg

供應(yīng)商: Click Chemistry Tools

產(chǎn)品貨號(hào): CCT-QBD-10181-1000

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/1000mg

產(chǎn)品說明書: 點(diǎn)擊查看

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產(chǎn)品新聞

背景資料: dPEG?4-SATA(產(chǎn)品編號(hào)QBD-10181)是一種親水性、水溶性的高度流行的硫醇化和交聯(lián)試劑(稱為SATA)。使用簡(jiǎn)單，容易的反應(yīng)，該試劑可用于硫醇化或交聯(lián)生物分子。

產(chǎn)品描述: dPEG?4-SATA, also known as S-acetyl-dPEG?4-NHS ester, product number QBD-10181, is one of Quanta BioDesign’s versions of the widely popular thiolation reagent N-succinimidyl-S-acetylthioacetate (SATA). The acetyl-protected thiol is separated from the N-hydroxysuccinimidyl (NHS) ester by an amphiphilic, discrete polyethylene glycol (dPEG?) spacer. The dPEG? spacer adds water solubility to the product.nThiolation is the process of adding a sulfhydryl group to a molecule. Bioconjugation frequently employs thiolation because the reactions to install thiol groups on molecules or to react molecules with sulfhydryl groups are simple and often chemoselective.nThe widely popular SATA reagent thiolates molecules with available amines via the NHS ester. Removal of the acetyl protecting group from the sulfhydryl permits crosslinking between the SATA-modified compound and a target molecule of interest that contains a thiol-reactive group, such as maleimide. Unfortunately, SATA is hydrophobic. Consequently, before use, SATA must be dissolved in a dry, water-miscible organic solvent.nVector Laboratories' dPEG?4-SATA inserts a single molecular weight tetraethylene glycol (dPEG?4) spacer between the protected thiol and the NHS ester. The dPEG? spacer imparts water solubility to the molecule, allowing dPEG?4-SATA to be dissolved and reacted in water without the need for an organic solvent. Also, the dPEG?4 spacer adds hydrodynamic volume to the molecule to which it is conjugated. Increasing the hydrodynamic volume reduces aggregation and precipitation of proteins conjugated to dPEG?4-SATA. Hydroxylamine hydrochloride (CAS number 5470-11-1) easily removes the acetyl protecting group, exposing the sulfhydryl moiety for further reaction. Any application that can be carried out with a traditional, non-PEGylated SATA reagent can be carried out with our SATA containing a dPEG? spacer.

產(chǎn)品形式: 淡黃色至琥珀色油狀物

保存建議

其他: Click Chemistry Tools（CCT）公司位于美國(guó)亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發(fā)和擴(kuò)展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。此外，CCT還可以提供個(gè)性化的定制產(chǎn)品，已滿足不同用戶的需求。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。nFluoroprobes公司位于美國(guó)亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發(fā)一系列的連接(linker)產(chǎn)品。利用特別新的研究成果研發(fā)生產(chǎn)出各類新穎的交聯(lián)和標(biāo)記試劑。其產(chǎn)品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術(shù)等領(lǐng)域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個(gè)性化需求提供各類定制連接產(chǎn)品。代表產(chǎn)品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標(biāo)記試劑盒等。nQuanta Biodesign公司位于美國(guó)中部的俄亥俄州，成立于1997年。也是專注于生產(chǎn)研發(fā)各類標(biāo)記產(chǎn)品的品牌之一。其研發(fā)的產(chǎn)品與dPEG技術(shù)相結(jié)合，生產(chǎn)出他們獨(dú)有的專利產(chǎn)品dPEG Building Blocks and Linkers，被廣泛用于細(xì)胞治療和分子診斷等研究領(lǐng)域。另外，還可為廣大科研工作者提供多種化學(xué)修飾試劑以及傳統(tǒng)Liner等。n目前上述三個(gè)品牌都已被被Vectorlabs收購(gòu)并整合到Vectorlabs產(chǎn)品中