Bis-MAL-賴氨酸-dPEG ?-MFP酯-1000 mg-Bis-MAL-Lysine-dPEG??-TFP ester-1000 mg代理/參數(shù)/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: Bis-MAL-賴氨酸-dPEG ?-MFP酯-1000 mg

英文名字: Bis-MAL-Lysine-dPEG??-TFP ester-1000 mg

供應(yīng)商: Click Chemistry Tools

產(chǎn)品貨號: CCT-QBD-10631-1000

產(chǎn)品報價: ￥詢價/1000mg

產(chǎn)品說明書: 點(diǎn)擊查看

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料: Bis-MAL-賴氨酸-dPEG ?4-TFP酯，產(chǎn)品號QBD-10631，是來自Vector Laboratories，Inc.的獨(dú)特交聯(lián)劑。賴氨酸的α(a)和β(e)胺用巰基反應(yīng)性馬來酰亞胺丙基官能化。賴氨酸的羧酸尾與含有胺反應(yīng)性2，3，5，6-四氟苯基(TFP)酯的單分子量離散聚乙二醇(dPEG?)間隔基綴合。從dPEG?間隔基的羰基碳到α-胺-綴合的馬來酰亞胺基團(tuán)的反應(yīng)性位點(diǎn)的距離為25個原子(18.773 π)長。從dPEG?間隔基的羰基碳到e-胺-綴合的馬來酰亞胺基團(tuán)的反應(yīng)性位點(diǎn)的距離為29個原子(26.105 π)長。

產(chǎn)品描述: Bis-MAL-Lysine-dPEG?4-TFP ester, product number QBD-10631, is a unique crosslinker from Vector Laboratories, Inc. The alpha (a) and epsilon (e) amines of lysine are functionalized with sulfhydryl-reactive maleimidopropyl groups. The carboxylic acid tail of lysine is conjugated to a single molecular weight, discrete polyethylene glycol (dPEG?) spacer containing an amine-reactive 2,3,5,6-tetrafluorophenyl (TFP) ester. The distance from the carbonyl carbon of the dPEG? spacer to the reactive site of the a-amine-conjugated maleimide group is 25 atoms (18.773 ?) long. The distance from the carbonyl carbon of the dPEG? spacer to the reactive site of the e-amine-conjugated maleimide group is 29 atoms (26.105 ?) long.nTFP esters react with primary and secondary amines to form stable amide bonds like the more widely used N-hydroxysuccinimidyl (NHS) esters. However, TFP esters demonstrate superior hydrolytic stability and higher reactivity with amines than NHS esters. The optimum pH for this reaction is 7.5 – 8.0. Thus, the product functions as a heterobifunctional crosslinker.nBy design, the two maleimide groups of Bis-MAL-Lysine-dPEG?4-TFP ester can be used to bridge disulfides. For example, this capability may be useful in antibodies following reduction of the disulfide groups. Moreover, the two maleimide groups can be used to dimerize small molecules or peptides, each of which possesses a single free thiol group. At pH 6.5 – 7.5, maleimide groups react chemoselectively with sulfhydryls. However, above pH 7.5, chemoselectivity is lost, as maleimide groups also will react with free amines.nPossible uses for Bis-MAL-Lysine-dPEG?4-TFP ester include the construction of antibody-drug conjugates (ADCs); immobilization of antibodies or antibody fragments on solid supports; and dimerization of sulfhydryl-containing peptides followed by crosslinking to an amine-modified surface.

產(chǎn)品形式: 白色至米色固體

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其他: Click Chemistry Tools（CCT）公司位于美國亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發(fā)和擴(kuò)展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。此外，CCT還可以提供個性化的定制產(chǎn)品，已滿足不同用戶的需求。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。nFluoroprobes公司位于美國亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發(fā)一系列的連接(linker)產(chǎn)品。利用特別新的研究成果研發(fā)生產(chǎn)出各類新穎的交聯(lián)和標(biāo)記試劑。其產(chǎn)品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術(shù)等領(lǐng)域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個性化需求提供各類定制連接產(chǎn)品。代表產(chǎn)品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標(biāo)記試劑盒等。nQuanta Biodesign公司位于美國中部的俄亥俄州，成立于1997年。也是專注于生產(chǎn)研發(fā)各類標(biāo)記產(chǎn)品的品牌之一。其研發(fā)的產(chǎn)品與dPEG技術(shù)相結(jié)合，生產(chǎn)出他們獨(dú)有的專利產(chǎn)品dPEG Building Blocks and Linkers，被廣泛用于細(xì)胞治療和分子診斷等研究領(lǐng)域。另外，還可為廣大科研工作者提供多種化學(xué)修飾試劑以及傳統(tǒng)Liner等。n目前上述三個品牌都已被被Vectorlabs收購并整合到Vectorlabs產(chǎn)品中