中文名稱

Lipoamido-dPEG

英文名字

Lipoamido-dPEG??-TFP ester-1000 mg

供應(yīng)商

Click Chemistry Tools

產(chǎn)品貨號(hào)

CCT-QBD-10641-1000

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/1000mg

產(chǎn)品說(shuō)明書

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購(gòu)買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料

Lipoamido-dPEG?4-TFP酯(產(chǎn)品編號(hào)QBD-10641)是金和銀表面(例如納米顆粒上)的單分子量離散PEG(dPEG?)改性劑。在24個(gè)原子長(zhǎng)的dPEG?間隔基的一端上的硫辛酸部分與金屬如金和銀形成配價(jià)鍵。TFP酯與游離胺反應(yīng)以形成游離胺，最佳在pH 7.5 - 8.0范圍內(nèi)。從硫辛酸環(huán)中的二硫鍵到與2，3，5，6-四氟苯酚(TFP)酯相鄰的羰基碳的距離為24個(gè)原子(28.0個(gè))。該產(chǎn)品的應(yīng)用包括在金屬表面上形成自組裝單分子層(SAM)，以及將肽和蛋白質(zhì)交聯(lián)和固定到金屬納米顆粒表面。

產(chǎn)品描述

Lipoamido-dPEG?4-TFP ester, product number QBD-10641, is a single molecular weight, discrete PEG (dPEG?) modifier of gold and silver surfaces, for example, on nanoparticles. The lipoic acid moiety on one end of the 24-atoms-long dPEG? spacer forms dative bonds with metals like gold and silver. The TFP ester reacts with free amines to form free amines, optimally in the pH range 7.5 - 8.0. The distance from the disulfide bond in the lipoic acid ring to the carbonyl carbon adjacent to the 2,3,5,6-tetrafluorophenol (TFP) ester, the distance is 24 atoms (28.0 ?). Applications for this product include creating self-assembled monolayers (SAMs) on metal surfaces and crosslinking and immobilizing peptides and proteins to the surfaces of metal nanoparticles.nLipoic acid, also known as alpha-lipoic acid, a-lipoic acid, and thioctic acid, consists of a five-membered ring containing a disulfide attached to a pentanoic acid group. As a naturally occurring antioxidant, lipoic acid functions as a cofactor in several enzyme systems. It is a bidentate thiol ligand that forms two stable dative bonds per lipoic acid group with gold, silver, and other metals. These dative bonds form with oxidized lipoic acid or reduced dihydrolipoic acid (DHLA). Because it forms two dative bonds on metal surfaces, lipoic acid is more stable than PEGylation reagents containing a single thiol. This increased stability prevents lipoic-acid-functionalized dPEG? products from being oxidized off the metal surface. The lipoic acid group forms dative bonds with metals with or without reduction to DHLA. If reduction to DHLA is preferred, Tris(2-carboxyethyl)phosphine (TCEP) will rapidly reduce lipoic acid to DHLA.nTFP esters react more readily with amines and possess better hydrolytic stability than N-hydroxysuccinimide (NHS). The superiority of PEG-TFP esters over NHS esters is documented in the scientific literature.nWhen using this product, it is typical to conjugate the carboxyl end of the dPEG? to an amine to form an amide bond before forming a dative bond between a metal surface and the lipoic acid moiety of Lipoamido-dPEG?4-TFP ester. The TFP ester reacts optimally at pH 7.5 – 8.0, but it will also react with amines at pH values above and below this range.nLipoamido-dPEG?4-TFP ester has limited solubility in water or aqueous buffer. We recommend using dry (over 3 ? molecular sieves) water-miscible solvents such as N, N-dimethylacetamide (DMAC) or acetonitrile to form a stock solution that can be added to aqueous buffer to carry out the reaction.

產(chǎn)品形式

淡黃色至琥珀色粘稠液體

保存建議

其他

Click Chemistry Tools（CCT）公司位于美國(guó)亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來(lái)，一致致力于不斷開發(fā)和擴(kuò)展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。此外，CCT還可以提供個(gè)性化的定制產(chǎn)品，已滿足不同用戶的需求。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。nFluoroprobes公司位于美國(guó)亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來(lái)，一直致力于不斷開發(fā)一系列的連接(linker)產(chǎn)品。利用特別新的研究成果研發(fā)生產(chǎn)出各類新穎的交聯(lián)和標(biāo)記試劑。其產(chǎn)品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術(shù)等領(lǐng)域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個(gè)性化需求提供各類定制連接產(chǎn)品。代表產(chǎn)品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標(biāo)記試劑盒等。nQuanta Biodesign公司位于美國(guó)中部的俄亥俄州，成立于1997年。也是專注于生產(chǎn)研發(fā)各類標(biāo)記產(chǎn)品的品牌之一。其研發(fā)的產(chǎn)品與dPEG技術(shù)相結(jié)合，生產(chǎn)出他們獨(dú)有的專利產(chǎn)品dPEG Building Blocks and Linkers，被廣泛用于細(xì)胞治療和分子診斷等研究領(lǐng)域。另外，還可為廣大科研工作者提供多種化學(xué)修飾試劑以及傳統(tǒng)Liner等。n目前上述三個(gè)品牌都已被被Vectorlabs收購(gòu)并整合到Vectorlabs產(chǎn)品中

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書確認(rèn)。

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