Lipoamido-dPEG-Lipoamido-dPEG???-TFP ester-1000 mg代理/參數(shù)/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: Lipoamido-dPEG

英文名字: Lipoamido-dPEG???-TFP ester-1000 mg

供應(yīng)商: Click Chemistry Tools

產(chǎn)品貨號: CCT-QBD-10814-1000

產(chǎn)品報價: ￥詢價/1000mg

產(chǎn)品說明書: 點(diǎn)擊查看

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料: Lipoamido-dPEG?12-TFP酯(產(chǎn)品編號QBD-10814)是一種單分子量、離散PEG(dPEG?)改性試劑。該產(chǎn)品由α-硫辛酸和在中等長度(48個原子)dPEG?間隔基的相對端上的2，3，5，6_四氟苯基(TFP)酯組成。硫辛酸基團(tuán)與金屬，特別是金和銀形成兩(2)配位共價鍵(配價鍵)。TFP酯與游離胺反應(yīng)形成酰胺鍵。該產(chǎn)品的應(yīng)用包括肽或蛋白質(zhì)固定在金屬表面上，在金屬表面上形成自組裝單分子層(SAM)和傳感器開發(fā)。

產(chǎn)品描述: Lipoamido-dPEG?12-TFP ester, product number QBD-10814, is a single molecular weight, discrete PEG (dPEG?) modification reagent. The product consists of alpha-lipoic acid and a 2,3,5,6-tetrafluorophenyl (TFP) ester on opposite ends of a medium-length (48 atoms) dPEG? spacer. The lipoic acid group forms two (2) coordinate covalent bonds (dative bonds) with metal, especially gold and silver. The TFP ester reacts with free amines to form amide bonds. Applications for this product include peptide or protein immobilization on metal surfaces, the formation of self-assembled monolayers (SAMs) on metal surfaces, and sensor development.nLipoic acid, also known as a-lipoic acid and thioctic acid, is a naturally occurring antioxidant that functions as a cofactor in several enzyme systems. It consists of a dithiolane ring (a five-membered ring containing a disulfide) attached to a pentanoic acid group. As a bidentate thiol ligand, lipoic acid forms two stable dative bonds per lipoic acid group with gold, silver, and other metals. These dative bonds form with oxidized lipoic acid or reduced dihydrolipoic acid (DHLA). Because it forms two dative bonds on metal surfaces, lipoic acid is more stable than PEGylation reagents containing a single thiol. This increased stability prevents lipoic-acid-functionalized dPEG? products from being oxidized off the metal surface.nWhen using this product, it is typical to begin with the conjugation of the carboxyl end of the dPEG? to an amino group to form an amide bond. TFP esters optimally react with amines at pH 7.5 – 8.0. As documented in the scientific literature, TFP esters react more readily with amines and possess better hydrolytic stability than N-hydroxysuccinimidyl (NHS) esters. nAfter reacting the TFP ester end of the molecule, the lipoic acid end of the dPEG? linker can be reacted with metals such as gold or silver. The lipoic acid group forms dative bonds with metals with or without reduction to DHLA. If reduction to DHLA is preferred, Tris(2-carboxyethyl)phosphine (TCEP) will reduce lipoic acid to DHLA rapidly.nLipoamido-dPEG?12-TFP ester dissolves in water or aqueous buffer and organic solvents. Stock solutions in water or aqueous buffer do not have long-term stability and should be used immediately. For stock solutions with long-term stability, we recommend dry (over 3 ? molecular sieves) water-miscible solvents such as N,N-dimethylacetamide (DMAC) or acetonitrile. Unused stock solutions in dry organic solvents should be stored at -20°C or colder.

產(chǎn)品形式: 黃色至琥珀色油狀物或蠟狀固體

保存建議

其他: Click Chemistry Tools（CCT）公司位于美國亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發(fā)和擴(kuò)展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。此外，CCT還可以提供個性化的定制產(chǎn)品，已滿足不同用戶的需求。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。nFluoroprobes公司位于美國亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發(fā)一系列的連接(linker)產(chǎn)品。利用特別新的研究成果研發(fā)生產(chǎn)出各類新穎的交聯(lián)和標(biāo)記試劑。其產(chǎn)品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術(shù)等領(lǐng)域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個性化需求提供各類定制連接產(chǎn)品。代表產(chǎn)品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標(biāo)記試劑盒等。nQuanta Biodesign公司位于美國中部的俄亥俄州，成立于1997年。也是專注于生產(chǎn)研發(fā)各類標(biāo)記產(chǎn)品的品牌之一。其研發(fā)的產(chǎn)品與dPEG技術(shù)相結(jié)合，生產(chǎn)出他們獨(dú)有的專利產(chǎn)品dPEG Building Blocks and Linkers，被廣泛用于細(xì)胞治療和分子診斷等研究領(lǐng)域。另外，還可為廣大科研工作者提供多種化學(xué)修飾試劑以及傳統(tǒng)Liner等。n目前上述三個品牌都已被被Vectorlabs收購并整合到Vectorlabs產(chǎn)品中