中文名稱

dPEG?乙酰基-SATA(S-乙酰基-dPEG?乙酰基-NHS酯)-1000 mg

英文名字

dPEG???-SATA (S-acetyl-dPEG???-NHS ester)-1000 mg

供應(yīng)商

Click Chemistry Tools

產(chǎn)品貨號

CCT-QBD-10852-1000

產(chǎn)品報價

￥詢價/1000mg

產(chǎn)品說明書

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購買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料

dPEG?12-SATA，也稱為S-乙酰基-dPEG?12-NHS酯，產(chǎn)品編號QBD-10852，是廣受歡迎的硫醇化試劑N-琥珀酰亞胺基-S-乙酰基硫代乙酸酯(SATA)的Quanta BioDesign版本之一。乙酰基保護的硫醇通過兩親性離散聚乙二醇(dPEG?)間隔基與N-羥基琥珀酰亞胺基(NHS)酯分離。中等長度(39個原子，46.8 μ m)的柔性dPEG?12間隔基使產(chǎn)品可溶于水。

產(chǎn)品描述

dPEG?12-SATA, also known as S-acetyl-dPEG?12-NHS ester, product number QBD-10852, is one of Quanta BioDesign’s versions of the widely popular thiolation reagent N-succinimidyl-S-acetylthioacetate (SATA). The acetyl-protected thiol is separated from the N-hydroxysuccinimidyl (NHS) ester by an amphiphilic, discrete polyethylene glycol (dPEG?) spacer. The medium-length (39 atoms, 46.8 ?), flexible dPEG?12 spacer makes the product water soluble.nThiolation is the process of adding a sulfhydryl group to a molecule. Bioconjugation frequently employs thiolation because the reactions to install thiol groups on molecules or to react molecules with sulfhydryl groups are simple and often chemoselective. The widely popular SATA reagent thiolates molecules with available amines via the NHS ester. Removal of the acetyl protecting group from the sulfhydryl permits crosslinking between the SATA-modified compound and a target molecule of interest that contains a thiol-reactive group, such as maleimide. Unfortunately, the classic SATA reagent is hydrophobic and must be dissolved in a dry, water-miscible organic solvent before use.nVector Laboratories' dPEG?12-SATA inserts a single molecular weight spacer between the protected thiol and the NHS ester. The dPEG? spacer imparts water solubility to the molecule, allowing dPEG?12-SATA to dissolve and react in water without the need for an organic solvent. Also, the dPEG?12 spacer adds hydrodynamic volume to the molecule to which it is conjugated, reducing aggregation and precipitation of proteins conjugated to dPEG?12-SATA. Hydroxylamine hydrochloride (CAS number 5470-11-1) easily removes the acetyl protecting group, exposing the sulfhydryl moiety for further reactions, for example, crosslinking to thiols or thiol-reactive groups like maleimides, bromoacetamides, and so forth. Any application that can be carried out with a traditional, non-PEGylated SATA reagent can be carried out with our SATA containing a dPEG? spacer.

產(chǎn)品形式

淺黃色至琥珀色油狀物;在儲存條件下可能凝固

保存建議

其他

Click Chemistry Tools（CCT）公司位于美國亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發(fā)和擴展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。此外，CCT還可以提供個性化的定制產(chǎn)品，已滿足不同用戶的需求。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。nFluoroprobes公司位于美國亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發(fā)一系列的連接(linker)產(chǎn)品。利用特別新的研究成果研發(fā)生產(chǎn)出各類新穎的交聯(lián)和標(biāo)記試劑。其產(chǎn)品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術(shù)等領(lǐng)域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個性化需求提供各類定制連接產(chǎn)品。代表產(chǎn)品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標(biāo)記試劑盒等。nQuanta Biodesign公司位于美國中部的俄亥俄州，成立于1997年。也是專注于生產(chǎn)研發(fā)各類標(biāo)記產(chǎn)品的品牌之一。其研發(fā)的產(chǎn)品與dPEG技術(shù)相結(jié)合，生產(chǎn)出他們獨有的專利產(chǎn)品dPEG Building Blocks and Linkers，被廣泛用于細胞治療和分子診斷等研究領(lǐng)域。另外，還可為廣大科研工作者提供多種化學(xué)修飾試劑以及傳統(tǒng)Liner等。n目前上述三個品牌都已被被Vectorlabs收購并整合到Vectorlabs產(chǎn)品中

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認。

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