MAL-dPEG?-Lys(-5(6)-羧基熒光素)-NH-m-dPEG?-NH-m-MAL-dPEG??-Lys(-5(6)-Carboxyfluorescein)-NH-m-dPEG???-5 mg代理/參數(shù)/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: MAL-dPEG?-Lys(-5(6)-羧基熒光素)-NH-m-dPEG?-NH-m

英文名字: MAL-dPEG??-Lys(-5(6)-Carboxyfluorescein)-NH-m-dPEG???-5 mg

供應(yīng)商: Click Chemistry Tools

產(chǎn)品貨號: CCT-QBD-11577-5

產(chǎn)品報價: ￥詢價/5mg

產(chǎn)品說明書: 點(diǎn)擊查看

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系。本公司所有產(chǎn)品僅供科研使用，不用于臨床診斷。

產(chǎn)品新聞

背景資料: MAL-dPEG?4-Lys(5(6)-羧基熒光素)-NH-m-dPEG?24，產(chǎn)品編號QBD-11577，是Vector Laboratories獨(dú)特的專利模塊化、可設(shè)計(jì)的有效載荷遞送試劑之一，稱為Sidewinder?。 Sidewinder?產(chǎn)品構(gòu)建在離散PEG(dPEG?)主鏈上，用于抗體-藥物綴合物(ADC)和相關(guān)構(gòu)建體。有效載荷(細(xì)胞毒素，染料，小分子)裝載到鏈的側(cè)臂上。遠(yuǎn)端的甲氧基封端的dPEG?24間隔基保護(hù)有效載荷并改變性能。nMAL-dPEG?4-Lys(5(6)-羧基熒光素)-NH-m-dPEG?24(產(chǎn)品編號QBD-11577)的馬來酰亞胺反應(yīng)性基團(tuán)通過硫醇-馬來酰亞胺反應(yīng)(邁克爾加成反應(yīng))與生物分子上的游離硫醇反應(yīng)。側(cè)臂用5(6)-羧基熒光素(ex/em = 493/517)官能化，并可用于追蹤細(xì)胞運(yùn)輸和綴合分子如抗體或抗體片段的內(nèi)化。nSidewinder?產(chǎn)品旨在幫助創(chuàng)建穩(wěn)定的高DAR ADC。已發(fā)表的研究表明，將疏水有效載荷(例如，細(xì)胞毒素)靠近抗體表面并用SuperHydrophilic? dPEG?構(gòu)建體保護(hù)它，通過許多功效測量比將有效載荷置于接頭的遠(yuǎn)端更好。該分子還可用于修飾和優(yōu)化BD、細(xì)胞運(yùn)輸和內(nèi)化、血清半衰期和免疫原性。“

產(chǎn)品描述: MAL-dPEG?4-Lys(5(6)-carboxyfluorescein)-NH-m-dPEG?24, product number QBD-11577, is one of Vector Laboratories' unique, patented class of modular, designable payload delivery reagents called Sidewinder?. Sidewinder? products are built on a discrete PEG (dPEG?) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain's sidearm. The distal end's methoxy-terminated dPEG?24 spacer protects payloads and modifies performance.nThe maleimide reactive group of MAL-dPEG?4-Lys(5(6)-carboxyfluorescein)-NH-m-dPEG?24, product number QBD-11577 reacts with free thiols on the biomolecule through the thiol-maleimide reaction (a Michael addition reaction). The sidearm is functionalized with 5(6)-carboxyfluorescein (ex/em = 493/517) and can be used to track cell trafficking and internalization of a conjugated molecule such as an antibody or antibody fragment.nSidewinder? products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload (e.g., a cytotoxin) close to the antibody surface and protecting it with a SuperHydrophilic? dPEG? construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also be used to modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.nThe dPEG? linkers and spacers in the Sidewinder? construct are uniform, single molecular-weight PEGs with discrete chain lengths. This differs from traditional, non-uniform polymer PEG linkers and spacers, which have a dispersed range of PEG chain lengths, each with a unique molecular weight. In contrast to dispersed polymer PEGs, dPEG? products are high-purity compounds with reproducible purity profiles.nSidewinder? molecules are also fully designable. MAL-dPEG?4-Lys(5(6)-carboxyfluorescein)-NH-m-dPEG?24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with different reactivities, change the maleimide attachment group to a different reactive group, and many more customizations. Please inquire about your specific needs.

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其他: Click Chemistry Tools（CCT）公司位于美國亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發(fā)和擴(kuò)展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。此外，CCT還可以提供個性化的定制產(chǎn)品，已滿足不同用戶的需求。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。nFluoroprobes公司位于美國亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發(fā)一系列的連接(linker)產(chǎn)品。利用特別新的研究成果研發(fā)生產(chǎn)出各類新穎的交聯(lián)和標(biāo)記試劑。其產(chǎn)品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術(shù)等領(lǐng)域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個性化需求提供各類定制連接產(chǎn)品。代表產(chǎn)品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標(biāo)記試劑盒等。nQuanta Biodesign公司位于美國中部的俄亥俄州，成立于1997年。也是專注于生產(chǎn)研發(fā)各類標(biāo)記產(chǎn)品的品牌之一。其研發(fā)的產(chǎn)品與dPEG技術(shù)相結(jié)合，生產(chǎn)出他們獨(dú)有的專利產(chǎn)品dPEG Building Blocks and Linkers，被廣泛用于細(xì)胞治療和分子診斷等研究領(lǐng)域。另外，還可為廣大科研工作者提供多種化學(xué)修飾試劑以及傳統(tǒng)Liner等。n目前上述三個品牌都已被被Vectorlabs收購并整合到Vectorlabs產(chǎn)品中