NH2O?-Glu(OH)-NH-m-dPEG??4.0-50 mg-NH?-dPEG??-Glu(OH)-NH-m-dPEG???-50 mg代理/參數(shù)/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: NH2O?-Glu(OH)-NH-m-dPEG??4.0-50 mg

英文名字: NH?-dPEG??-Glu(OH)-NH-m-dPEG???-50 mg

供應商: Click Chemistry Tools

產品貨號: CCT-QBD-11643-50

產品報價: ￥詢價/50mg

產品說明書: 點擊查看

購買方式: 銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網銀支付，或直接與我們電話聯(lián)系。本公司所有產品僅供科研使用，不用于臨床診斷。

產品新聞

背景資料: NH 2-dPEG?4-Glu(OH)-NH-m-dPEG?24，產品編號QBD-11643，是Vector Laboratories獨特的專利模塊化、可設計的有效載荷遞送試劑之一，稱為Sidewinder?。Sidewinder?產品構建在離散PEG(dPEG?)主鏈上，用于抗體-藥物綴合物(ADC)和相關構建體。有效載荷(細胞毒素，染料，小分子)裝載到鏈的側臂上。遠端的甲氧基封端的dPEG?24間隔基保護有效載荷并改變性能。NH 2-dPEG?4-Glu(OH)-NH-m-dPEG?24的游離伯胺QBD-11643與羧酸及其活性酯(TFP酯、NHS酯)反應形成穩(wěn)定的酰胺鍵。它是Sidewinder?與生物分子的連接點(例如，mAb、Fab、Fab '、靶向肽等)。主鏈含有一個與游離胺反應的羧酸側臂。在連接點氨基的反應、保護或官能化之后，羧酸側臂可以綴合至含胺的有效負載。綴合可以直接使用EDC或另一種合適的雙酰亞胺進行。或者，羧酸可以用N-羥基琥珀酰亞胺(NHS)或2，3，5，6-四氟苯酚(TFP)官能化以形成活性酯，其然后可以與含游離胺的有效載荷反應。Sidewinder?產品旨在幫助創(chuàng)建穩(wěn)定的高DAR ADC。已發(fā)表的研究表明，將疏水性有效負載靠近抗體表面并用SuperHydrophilic? dPEG?構建體保護它，在許多功效指標上都比將有效負載置于接頭遠端更好。該分子還可以修飾和優(yōu)化BD、細胞運輸和內化、血清半衰期和免疫原性。

產品描述: NH2-dPEG?4-Glu(OH)-NH-m-dPEG?24, product number QBD-11643, is one of Vector Laboratories' unique, patented class of modular, designable payload delivery reagents called Sidewinder?. Sidewinder? products are built on a discrete PEG (dPEG?) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain's sidearm. The distal end's methoxy-terminated dPEG?24 spacer protects payloads and modifies performance.nThe free primary amine of NH2-dPEG?4-Glu(OH)-NH-m-dPEG?24, QBD-11643, reacts with carboxylic acids and their active esters (TFP esters, NHS esters) to form stable amide bonds. It is the attachment point for the Sidewinder? to the biomolecule (e.g., mAb, Fab, Fab', targeting peptide, and so forth). The backbone contains one carboxylic acid sidearm that reacts with free amines. Following reaction, protection, or functionalization of the attachment point amino group, the carboxylic acid sidearm can be conjugated to an amine-containing payload. The conjugation can be done directly using EDC or another suitable carbodimide. Alternatively, the carboxylic acid can be functionalized with N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) to form the active ester, which can then be reacted with a free amine-containing payload.nSidewinder? products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload close to the antibody surface and protecting it with a SuperHydrophilic? dPEG? construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.nThe dPEG? linkers and spacers in the Sidewinder? construct are uniform, single molecular-weight PEGs with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have a dispersed range of PEG chain lengths, each with a unique molecular weight. Unlike dispersed polymer PEGs, dPEG? products are high-purity compounds with reproducible purity profiles.nSidewinder? molecules are also fully designable. NH2-dPEG?4-Glu(OH)-NH-m-dPEG?24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with other reactivities, change the amine attachment group to another reactive group, and many more customizations. Please inquire about your specific needs.

產品形式: 白色至類白色固體

保存建議

其他: Click Chemistry Tools（CCT）公司位于美國亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發(fā)和擴展一系列連接產品。他們利用特別新的研究成果研發(fā)生產出新穎的交聯(lián)和標記試劑。產品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術等。此外，CCT還可以提供個性化的定制產品，已滿足不同用戶的需求。目前CCT的產品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標記試劑盒以及分選用底物等。nFluoroprobes公司位于美國亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發(fā)一系列的連接(linker)產品。利用特別新的研究成果研發(fā)生產出各類新穎的交聯(lián)和標記試劑。其產品被廣泛用于藥物研發(fā)與篩選、疾病治療方法和診斷技術等領域。此外，F(xiàn)luoroprobes還可以根據(jù)客戶的個性化需求提供各類定制連接產品。代表產品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標記試劑盒等。nQuanta Biodesign公司位于美國中部的俄亥俄州，成立于1997年。也是專注于生產研發(fā)各類標記產品的品牌之一。其研發(fā)的產品與dPEG技術相結合，生產出他們獨有的專利產品dPEG Building Blocks and Linkers，被廣泛用于細胞治療和分子診斷等研究領域。另外，還可為廣大科研工作者提供多種化學修飾試劑以及傳統(tǒng)Liner等。n目前上述三個品牌都已被被Vectorlabs收購并整合到Vectorlabs產品中