非放射性碘測定試劑盒-Non-radioactive Iodide Assay kit代理/參數(shù)/廠家-免疫學試劑盒-艾美捷科技有限公司

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中文名稱: 非放射性碘測定試劑盒

英文名字: Non-radioactive Iodide Assay kit

供應商: Bertin Bioreagent

產品貨號: D05076

產品報價: ￥詢價/96wells

產品說明書: 點擊查看

購買方式: 90%產品中國有現(xiàn)貨庫存。銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

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背景資料: Present in nature in the form of iodide and iodate, iodine is a solid halogen at normal temperature. It is used in medicine, in the pharmaceutical and food industry. Food is the principal daily supply of iodide in human body [1].|Iodide is important in basal metabolism and permits temperature regulation, intellectual development for children, muscular development, normal heart function and growth of skeleton. Iodide transport is the basis for an emerging approach of selective cancer cell destruction. [2-3]|Iodide uptake from blood into thyroid follicular cells is the first step in the biosynthesis of thyroid hormones T4 and T3, known to regulate many essential biological processes [4-5].|Thyroid hormones are indispensable for body development. This transport is mediated by NIS (sodium iodide symporter), an intrinsic membrane glycoprotein located in the basolateral membrane of thyrocytes.|Since the discovery of NIS, thorough biochemical analysis has elucidated the mechanism of basolateral iodide transport and revealed the key role of NIS in thyroid diseases such as thyroid cancer, autoimmune disease, and congenital hypothyroidism [6].|If rate is not in the normal proportion, some diseases can be developed as underactive thyroid if the rate is too down or overactive thyroid if the rate is too up. Other diseases exist as chronic thyroiditis of Hashimoto or cancer of the thyroid gland [7].|Iodide deficiency is at origins of many thyroid metabolism disorders, this is why it is important to control rate of iodide to prevent all of these diseases.|This Iodide Assay is based on the oxido-reduction reaction: cerium(IV) is reduced by arsenic(III). The reduction of yellow (420 nm) cerium(IV) to colorless cerium(III) by arsenic(III) proceeds very slowly but traces of iodide strongly accelerate this reaction with the rate being directly proportional to iodide concentration.|For a given time, decay is inversely proportional to iodide
concentration in well. This method is simple and nonradioactive, and as such it can be used widely.

產品描述: 在自然界中以碘化物和碘酸鹽的形式存在，碘在常溫下是固體鹵素。它用于醫(yī)藥、制藥和食品工業(yè)。食物是人體碘的主要日常供應來源[1]。|碘化物在基礎代謝中很重要，可以調節(jié)體溫、促進兒童智力發(fā)育、肌肉發(fā)育、正常心臟功能和骨骼生長。碘離子轉運是選擇性癌細胞破壞的新興方法的基礎。[2-3]|從血液中攝取碘進入甲狀腺濾泡細胞是甲狀腺激素T4和T3生物合成的第一步，已知其調節(jié)許多基本生物過程[4-5]。|甲狀腺激素是身體發(fā)育不可缺少的。這種轉運由NIS（鈉碘同向轉運體）介導，NIS是位于甲狀腺細胞基底外側膜的內在膜糖蛋白。|自NIS發(fā)現(xiàn)以來，全面的生化分析已經闡明了基底外側碘轉運的機制，并揭示了NIS在甲狀腺疾病（如甲狀腺癌、自身免疫性疾病和先天性甲狀腺功能減退癥）中的關鍵作用[6]。|如果比率不處于正常比例，如果比率太低，一些疾病可以發(fā)展為甲狀腺功能低下，如果比率太高，則為甲狀腺功能亢進。其他疾病如橋本慢性甲狀腺炎或甲狀腺癌[7]。|碘缺乏是許多甲狀腺代謝紊亂的起源，這就是為什么控制碘的比率以預防所有這些疾病是重要的。|該碘化物含量測定基于氧化還原反應：鈰（IV）被砷（III）還原。砷（III）將黃色（420 nm）鈰（IV）還原成無色鈰（III）進行得非常緩慢，但痕量的碘化物強烈加速該反應，其速率與碘化物濃度成正比。|對于給定的時間，衰變與碘化物成反比濃度很好。該方法簡單、無放射性，具有廣泛的應用前景。

產品特點: 該非放射性碘測定試劑盒,Non-radioactive Iodide Assay kit產品產品特點詳情查看產品說明書。

保存建議: Store at +4degrees; shelf life 1 years maximum after production

其他: 法國Bertin Technologies公司是一家大型儀器設備及試劑供應商，擁有50多年的歷史，產品涉及衛(wèi)生、環(huán)境、安全甚至軍工等諸多領域。Bertin Bioreagent是Bertin Technologies集團的生物試劑部門，主要是致力于研發(fā)與炎癥，氧化損傷，內分泌學，糖尿病，肥胖癥，高血壓，精神藥理學，癌癥，哮喘，朊病毒疾病，藥代動力學和代謝等相關的化學試劑，蛋白，底物，抗體及檢測試劑盒等產品。 Bertin Instruments是Bertin Technologies集團的儀器部門，其中旗艦產品Precellys系列多功能生物樣品勻漿器是全世界各個實驗室的明星產品，截至目前累計有15000+的引文！