TIGIT 抗體 [7E5]-TIGIT Antibody [7E5]代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

免疫原: TIGIT antibody was raised against the extracellular domain of human TIGIT.

保存建議: TIGIT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

其他: ProSci Incorporated于1998年成立于美國(guó)加州圣地亞哥市,從事抗體等科研試劑的研發(fā)、生產(chǎn)和銷售。產(chǎn)品涵蓋了細(xì)胞凋亡、信號(hào)轉(zhuǎn)導(dǎo)、免疫、腫瘤、細(xì)胞生物、神經(jīng)生物、傳染病等領(lǐng)域。ProSci擁有超過(guò)30000種單克隆抗體和多克隆抗體。ProSci的抗體大都經(jīng)免疫親和層析純化,具有高純度、高親和力、特異性強(qiáng)等特點(diǎn),所有的ProSci抗體都經(jīng)過(guò)了嚴(yán)格的驗(yàn)證測(cè)試和質(zhì)量控制,已保證高質(zhì)量的產(chǎn)品。此外,ProSci還提供標(biāo)記二抗,重組蛋白,細(xì)胞和組織裂解液,細(xì)胞涂片,組織切片,多肽等產(chǎn)品與抗體配套使用。