Plasmid p-HMG1tag is derived from plasmid p-mHMG1, and expresses mouse HMGB1 containing the HA epitope, for detection with anti-HA monoclonal antibody (Falciola et al. High mobility group 1 protein is not stably associated with the chromosomes of somatic cells. J Cell Biol 1997, 137: 19-26).nnMouse HMGB1 contains only 2 conservative substitutions with respect to human HMGB1.nWhen transfected in mammalian cells, this plasmid increases transiently the HMGB1 content 4- to 7-fold.
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HMGBiotech是一家由HMGB領(lǐng)域的領(lǐng)先科學(xué)家Marco E. Bianchi創(chuàng)立的生物技術(shù)公司。nHMGBiotech是HMGB52質(zhì)量控制氧化還原變體的唯一生產(chǎn)商。該公司為活躍在這一有前途的領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法,并幫助Bianchi實(shí)驗(yàn)室(the Bianchi lab)開(kāi)發(fā)檢測(cè)和試劑。