- 中文名稱
熱休克同源蛋白70（HSP73）抗體
- 英文名字
- HSC70 (HSP73) Antibody
- 供應(yīng)商
- StressMarq
- 產(chǎn)品貨號(hào)
- SMC-151A
- 產(chǎn)品報(bào)價(jià)
- ￥已停產(chǎn)
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購(gòu)買方式
- StressMarq中國(guó)區(qū)現(xiàn)貨中心已經(jīng)建立，90%產(chǎn)品中國(guó)有現(xiàn)貨庫(kù)存。銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868
- 產(chǎn)品新聞
- 背景資料
- HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (5).nWhen cells are subjected to metabolic stress (e.g., heat shock) a member of the HSP 70 family, HSP 70 (HSP72), is expressed; HSP 70 is highly related to HSC70 (>90% sequence identity). Constitutively expressed HSC70 rapidly forms a stable complex with the highly inducible HSP70 in cells following heat shock. The interaction of HSC70 with HSP 70 is regulated by ATP. These two heat shock proteins move together in the cell experiencing stress. Furthermore, research on HSC70 has implicates it with a role in facilitating the recovery of centrosomal structure and function after heat shock (6).
- 應(yīng)用類型
- WB | IHC | ICC/IF | IP | ELISA | PLA | PBA | AM
- 免疫原
- 人 Hsc70全長(zhǎng)蛋白
- 來源宿主
- 小鼠
- 反應(yīng)性
- 人 | 小鼠 | 大鼠
- 保存建議
- 廠家推薦藍(lán)冰運(yùn)輸。收到產(chǎn)品后建議保存于-20oC。
- 其他
- StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務(wù)范圍遍及全球50多個(gè)國(guó)家。 StressMarq公司的核心技術(shù)領(lǐng)域?yàn)榧?xì)胞應(yīng)激（尤其是熱休克蛋白（HSP）領(lǐng)域，領(lǐng)先全球），離子通道，載體研究，同時(shí)在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到：細(xì)胞凋亡、細(xì)胞信號(hào)、通路和轉(zhuǎn)運(yùn)、細(xì)胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運(yùn)輸?shù)取３颂峁┯糜谶M(jìn)一步研究的相關(guān)工具外，StressMarq還提供全新的尖端研究工具，用于開發(fā)新的生物項(xiàng)目，包括全球獨(dú)一無二的A B晶體蛋白ELISA試劑盒（現(xiàn)在是公認(rèn)的乳腺癌標(biāo)志物）；熱休克同源蛋白70（Hsc70）ELISA試劑盒；以及用于神經(jīng)衰退研究的Tau活性蛋白與A-突觸核蛋白。本公司已將專業(yè)技術(shù)擴(kuò)展到抗體、小分子離子通道與載體等更新領(lǐng)域，前者包括當(dāng)前熱門的核心領(lǐng)域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括當(dāng)前熱門的核心領(lǐng)域：ENaC、NCC和NKCC2以及主要水通道蛋白載體。
- 注意
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該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說明書為準(zhǔn)。下單前，請(qǐng)瀏覽說明書確認(rèn)。
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