熱休克蛋白70 抗體-HSP70 Antibody代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 熱休克蛋白70 抗體

英文名字: HSP70 Antibody

供應(yīng)商: StressMarq

產(chǎn)品貨號: SMC-162C

產(chǎn)品報價: ￥已停產(chǎn)

產(chǎn)品說明書: 點擊查看

購買方式: StressMarq中國區(qū)現(xiàn)貨中心已經(jīng)建立，90%產(chǎn)品中國有現(xiàn)貨庫存。銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

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背景資料: HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (5).nAll HSP70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of HSP70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at amyjet.com.

應(yīng)用類型: WB | IHC | ICC/IF | IP | AM

免疫原: 大腸桿菌中超表達的重組人Hsp70

來源宿主: 小鼠

反應(yīng)性: 人 | 小鼠 | 大鼠 | 兩棲動物 | 雞 | 魚 | 酵母菌 | 果蠅

保存建議: 廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務(wù)范圍遍及全球50多個國家。 StressMarq公司的核心技術(shù)領(lǐng)域為細胞應(yīng)激（尤其是熱休克蛋白（HSP）領(lǐng)域，領(lǐng)先全球），離子通道，載體研究，同時在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到：細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運輸?shù)取３颂峁┯糜谶M一步研究的相關(guān)工具外，StressMarq還提供全新的尖端研究工具，用于開發(fā)新的生物項目，包括全球獨一無二的A B晶體蛋白ELISA試劑盒（現(xiàn)在是公認的乳腺癌標(biāo)志物）；熱休克同源蛋白70（Hsc70）ELISA試劑盒；以及用于神經(jīng)衰退研究的Tau活性蛋白與A-突觸核蛋白。本公司已將專業(yè)技術(shù)擴展到抗體、小分子離子通道與載體等更新領(lǐng)域，前者包括當(dāng)前熱門的核心領(lǐng)域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括當(dāng)前熱門的核心領(lǐng)域：ENaC、NCC和NKCC2以及主要水通道蛋白載體。