The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2).nENaCs are composed of three structurally related subunits that form a tetrameric channel, A, B, and gamma. The expression of its A and B subunits is enhanced as keratinocytes differentiate (3, 4). The B and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of A-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
應用類型
WB | IHC
免疫原
大鼠ENaC B 羧基末端合成肽 (aa. 617-638)
來源宿主
小鼠
反應性
小鼠
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務范圍遍及全球50多個國家。 StressMarq公司的核心技術領域為細胞應激(尤其是熱休克蛋白(HSP)領域,領先全球),離子通道,載體研究,同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到:細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外,StressMarq還提供全新的尖端研究工具,用于開發(fā)新的生物項目,包括全球獨一無二的A B晶體蛋白ELISA試劑盒(現在是公認的乳腺癌標志物);熱休克同源蛋白70(Hsc70)ELISA試劑盒;以及用于神經衰退研究的Tau活性蛋白與A-突觸核蛋白。本公司已將專業(yè)技術擴展到抗體、小分子離子通道與載體等更新領域,前者包括當前熱門的核心領域:Nav、Cav、TRP、Kv、KCNQ、HCN,后者包括當前熱門的核心領域:ENaC、NCC和NKCC2以及主要水通道蛋白載體。