Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the B subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).
應用類型
WB | IHC | ICC/IF
免疫原
人Ankyrin-R融合蛋白氨基酸序號1-1881 (全長)
來源宿主
小鼠
反應性
人 | 小鼠 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務范圍遍及全537多個國家。 StressMarq公司的核心技術領域為細胞應激(尤其是熱休克蛋白(HSP)領域,領先全球),離子通道,載體研究,同時在神經(jīng)科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領域涉及到:細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經(jīng)生物學、神經(jīng)科學、氧化應激、磷酸化運輸?shù)取3颂峁┯糜谶M一步研究的相關工具外,Str