細(xì)胞外信號(hào)調(diào)節(jié)激酶1/2 抗體-Erk1/2 Antibody: Dylight 633代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 細(xì)胞外信號(hào)調(diào)節(jié)激酶1/2 抗體

英文名字: Erk1/2 Antibody: Dylight 633

供應(yīng)商: StressMarq

產(chǎn)品貨號(hào): SPC-120D-DY633

產(chǎn)品報(bào)價(jià): ￥已停產(chǎn)

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背景資料: The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called p44 and p42 MAP kinases, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. Because the 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade, the two proteins are often referred to collectively as ERK1/2 or p44/p42 MAP kinase (1). They are both located in the cytosol and mitochondria (2). While the role of cytosol ERK1/2 is well studied and involved in multiple cellular functions (2), the role of mitochondrial ERK1/2 remains poorly understood.nBoth ERK 1 and 2 are activated by MEK1 or MEK2, by dual phosphorylation of a threonine and tyrosine residue in the activation loop (TEY motif) (1, 3). Either phosphorylation alone can induce an electrophoretic mobility shift, but both are required for activation of the kinase. This dual phosphorylation is efficiently detected by phosphorylation state-specific antibody directed to the pTEpY motif. Once activated, MAP kinases phosphorylate a broad spectrum of substrates, including cytoskeletal proteins, translation regulators, transcription factors, and the Rsk family of protein kinases (4). ERK1/2 activation is generally thought to confer a survival advantage to cells (5); however there is increasing evidence that suggests that the activation of ERK1/2 also contributes to cell death under certain conditions (5). ERK1/2 also is activated in neuronal and renal epithelial cells upon exposure to oxidative stress and toxicants or deprivation of growth factors, and inhibition of the ERK pathway blocks apoptosis (5).

應(yīng)用類型: WB | IHC | ICC/IF | FCM

免疫原: 長(zhǎng)35AA的殘基合成肽, Erk1 MAP 激酶加上CGG 聯(lián)接基團(tuán), 鑰孔蟲戚血藍(lán)素螯合

來(lái)源宿主: 兔

反應(yīng)性: 人 | 小鼠 | 大鼠 | 牛 | 綿羊 | 雞 | 果蠅 | 非洲爪蟾

保存建議: 廠家推薦藍(lán)冰運(yùn)輸。收到產(chǎn)品后建議保存于-20oC。

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務(wù)范圍遍及2560多個(gè)國(guó)家。 StressMarq公司的核心技術(shù)領(lǐng)域?yàn)榧?xì)胞應(yīng)激（尤其是熱休克蛋白（HSP）領(lǐng)域，領(lǐng)先全球），離子通道，載體研究，同時(shí)在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到：細(xì)胞凋亡、細(xì)胞信號(hào)、通路和轉(zhuǎn)運(yùn)、細(xì)胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運(yùn)輸?shù)取３颂峁┯糜谶M(jìn)一步研究的相關(guān)工具外，Str