鈣網(wǎng)蛋白抗體-Calreticulin Antibody: Dylight 633代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 鈣網(wǎng)蛋白抗體

英文名字: Calreticulin Antibody: Dylight 633

供應(yīng)商: StressMarq

產(chǎn)品貨號: SPC-122B-DY633

產(chǎn)品報價: ￥已停產(chǎn)

產(chǎn)品說明書: 點擊查看

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背景資料: Calreticulin is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus (1-3). CRT’s three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2+ with high affinity and shares homology with calnexin (CNX) and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity (1,3). Recent studies suggest that this soluble ER protein has a multifunctional role. It appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. It has been shown to interact with the cytoskeleton and to be involved in the regulation of gene expression. Calreticulin may also play a role in cellular proliferation including its apparent activity in the proliferation of certain viruses within mammalian host cells (4, 5), and it has also been shown to be induced in response to various types of cell stress including amino acid deprivation (6). Close interconnections among protein synthesis, gene expression and calcium signaling have been observed by many researchers in recent years. Calreticulin might be centrally located and therefore it crucially participates in the coordination of many functions by the cell (4, 5). Studies also suggest its involvement in a few diseases such as systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis (1).

應(yīng)用類型: WB | IHC | ICC/IF | IP | FCM

免疫原: 加了半胱氨酸殘基的人鈣網(wǎng)蛋白合成肽, 鑰孔蟲戚血藍素螯合

來源宿主: 兔

反應(yīng)性: 人 | 小鼠 | 大鼠 | 牛 | 狗 | 雞 | 豚鼠 | 猴 | 豬 | 倉鼠 | 兔 | 綿羊

保存建議: 廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務(wù)范圍遍及2586多個國家。 StressMarq公司的核心技術(shù)領(lǐng)域為細胞應(yīng)激（尤其是熱休克蛋白（HSP）領(lǐng)域，領(lǐng)先全球），離子通道，載體研究，同時在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到：細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運輸?shù)取３颂峁┯糜谶M一步研究的相關(guān)工具外，Str