A晶狀體蛋白B抗體-Alpha B Crystallin Antibody: Dylight 594代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: The A-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The A-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into A, B and gamma families. A and B families are further divided into acidic and basic groups (A-A and A-B respectively). In the lens, A-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, A-crystallin enters its’ phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, A-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both A-A and B prevent apoptosis by inhibiting caspases (8). Specifically, A-B cystallin is found in many cells and organs outside the lens, and A B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍及2636多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經(jīng)科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經(jīng)生物學、神經(jīng)科學、氧化應激、磷酸化運輸?shù)取３颂峁┯糜谶M一步研究的相關工具外，Str