干擾素y抗體-IFN gamma Antibody: Dylight 488代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: Interferon gamma (IFNy) is a dimerized soluble cytokine that is the only member of the type II class of interferons. It is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens. IFN-gamma production modulates T cell growth and differentiation and inhibits the growth of B cells. Synthesis of IFN-gamma is inducible by IL-2, FGF and EGF. The active form of IFN-gamma is a homodimer with each subunit containing six helices. The dimeric structure of human IFN-gamma is stabilized by non-covalent interactions through the interface of the helices. IFN-gamma tranlsated precursor is 166 amino acids, including the 23 amino acid secretory sequence. 20 kDa and 25 kDa forms exist due to variable glycosylation; 40-60 kDa forms are observable under non-denaturing conditions as dimers and tetramers.

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