Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.
應(yīng)用類型
WB
免疫原
合成肽 aa.291~295(G-G-R-D-S)
來源宿主
兔
反應(yīng)性
人 | 小鼠 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務(wù)范圍遍17269多個國家。 StressMarq公司的核心技術(shù)領(lǐng)域為細胞應(yīng)激(尤其是熱休克蛋白(HSP)領(lǐng)域,領(lǐng)先全球),離子通道,載體研究,同時在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到:細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運輸?shù)取3颂峁┯糜谶M一步研究的相關(guān)工具外,Str????廚?????坊?????????????◢???軈?se