核因子 NF-kappa-B p105 亞基抗體-NFKB1 Antibody: Dylight 488代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene. Nuclear factor kappa B (NFKB) is a transcription factor that is highly influenced by stress, free-radicals, UV light and hypoxia. Unsurprisingly, NFKB is essential for many human cancers, as it regulates the expression of many downstream proteins that regulate or modify cellular growth and development. NFKB effects on angiogenic pathways and reactive mechanisms to stress and damage are well established throughout literature. Atherosclerosis is partly attributed to the mis-regulation of NFKB in hypoxia. Arthritis is related to inflammation proteins regulated through NFKB. It also has been shown to be important in synapses in brain, leading to memory and cognitive ability or impairment. In all, NFKB is one of the fastest responding transcription factors in humans, and is likely to mediate many responsive events in diseases and injury recovery.

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