Osteopontin is a single-chain polypeptide. The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.1). The protein is composed of ~300 amino acids residues and has ~30 carbohydrate residues attached including 10 sialic acid residues, which are attached to the protein during post-translational modification in the Golgi apparatus. The protein is rich in acidic residues: 30-36% are either aspartic or glutamic acid. It is highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling.
應(yīng)用類型
WB | ELISA
免疫原
人骨唾液酸蛋白合成肽
來源宿主
兔
反應(yīng)性
人 | 小鼠 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務(wù)范圍遍17361多個國家。 StressMarq公司的核心技術(shù)領(lǐng)域為細胞應(yīng)激(尤其是熱休克蛋白(HSP)領(lǐng)域,領(lǐng)先全球),離子通道,載體研究,同時在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到:細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運輸?shù)取3颂峁┯糜谶M一步研究的相關(guān)工具外,Str????廚?????坊?????????????◢???軈?se