RUNX2 (Runt-related transcription Factor) is a transcription factor that binds to its canonical consensus sequence 5’- PYGPYGGT-3’ in a number of promoters and enhancers. Through interaction with Twist 1 and Twist 2, RUNX2 regulates osteocalcin transcription, following parathyroid hormone signaling for bone loss repair. Ossification in skeletal formation is also partially regulated through RUNX2. Essentially, this transcription factor is responsible for many developmental and repair mechanisms in bone and collagen. Mutations in Cbfa1/Runx2 are associated with the disease Cleidocranial dysostosis.
應(yīng)用類型
WB | IHC | ICC/IF
免疫原
人RUNX2合成肽
來源宿主
兔
反應(yīng)性
人 | 小鼠
保存建議
廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務(wù)范圍遍17507多個國家。 StressMarq公司的核心技術(shù)領(lǐng)域為細胞應(yīng)激(尤其是熱休克蛋白(HSP)領(lǐng)域,領(lǐng)先全球),離子通道,載體研究,同時在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到:細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運輸?shù)取3颂峁┯糜谶M一步研究的相關(guān)工具外,Str????廚?????坊?????????????◢???軈?se