Catenin B-1 also known as B-catenin is a protein that in humans is encoded by the CTNNB1 gene. B-catenin is the first characterized member of the B -catenin family. B-catenin contains 12 ARM repeats and has a dual function, depending on its localization. Cytoplasmic B-catenin is a critical component of E-cadherin/catenin adhesion complexes and regulates cadherin-dependent cell-cell interactions. When localized to the nucleus, B -catenin regulates binding to transcription factors from the TCF/LEF family, activating transcription. B -catenin is expressed in hair follicle cells such as those found in the inner and outer portions of the root sheaths, and the basal and peripheral matrix cells. Expression has also been observed in colon tissue. Defects in expression have been linked to the development of several tumors and cancers.
應(yīng)用類型
WB
免疫原
人B-catenin 酪氨酸654磷酸化位置 (A-T-YP-A-A) 附近 (未磷酸化的).
來源宿主
兔
反應(yīng)性
人 | 小鼠 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務(wù)范圍遍17671多個國家。 StressMarq公司的核心技術(shù)領(lǐng)域為細胞應(yīng)激(尤其是熱休克蛋白(HSP)領(lǐng)域,領(lǐng)先全球),離子通道,載體研究,同時在神經(jīng)科學領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到:細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標志物、熱休克、神經(jīng)生物學、神經(jīng)科學、氧化應(yīng)激、磷酸化運輸?shù)取3颂峁┯糜谶M一步研究的相關(guān)工具外,Str????廚?????坊?????????????◢???軈?se