Ras-相關蛋白 Rab-5A 抗體-Rab5 Antibody: Dylight 488代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Ras-相關蛋白 Rab-5A 抗體

英文名字: Rab5 Antibody: Dylight 488

供應商: StressMarq

產(chǎn)品貨號: SPC-168D-DY488

產(chǎn)品報價: ￥已停產(chǎn)

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購買方式: StressMarq中國區(qū)現(xiàn)貨中心已經(jīng)建立，90%產(chǎn)品中國有現(xiàn)貨庫存。銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

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背景資料: Rab5 is a 24kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP -bound inactive and GTP-bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs) (1, 2). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment (3). Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion(1). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hyper variable COHO-terminal domains with a cysteine motif implicated in subcellular targeting. Post-translational modification of the cysteine motif with one or two geranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins(3). Each Rab shows a characteristic subcellular distribution (4).nIn particular, Rab5 is ubiquitously expressed in human tissues. It localizes mainly to early endosomes, but is also present on the plasma membrane. It regulates the fusion between endocytic vesicles and early endosomes, as well as the homotypic fusion between early endosomes (5). Among the proteins recruited by the GTP-bound active Rab5 are Rabaptin-5 and EEA1 (6). Anti-Rab5 may be used as an early endosome marker.

應用類型: WB | IHC | ICC/IF

免疫原: 人 Rab5 合成肽, 鑰孔蟲戚血藍素螯合; 與狗Rab5 對應氨基酸序列相同

來源宿主: 兔

反應性: 人 | 小鼠 | 大鼠 | 牛 | 猴

保存建議: 廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍及3057多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經(jīng)科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經(jīng)生物學、神經(jīng)科學、氧化應激、磷酸化運輸?shù)取３颂峁┯糜谶M一步研究的相關工具外，Str