p38 抗體-p38 Antibody: APC/Cy7代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: p38 抗體

英文名字: p38 Antibody: APC/Cy7

供應商: StressMarq

產(chǎn)品貨號: SPC-172D-APCCY7

產(chǎn)品報價: ￥已停產(chǎn)

產(chǎn)品說明書: 點擊查看

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背景資料: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2A translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 A has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).

應用類型: WB | IHC | ICC/IF | IP

免疫原: 加了半胱氨酸的人 p38合成肽, 長20 AA, 鑰孔蟲戚血藍素螯合.

來源宿主: 兔

反應性: 人 | 小鼠 | 大鼠 | 牛 | 猴 | 兔 | 豬 | 狗 | 倉鼠 | 雞 | 綿羊 | 豚鼠

保存建議: 廠家推薦藍冰運輸。收到產(chǎn)品后建議保存于-20oC。

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍及3130多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經(jīng)科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領域涉及到：細胞凋亡、細胞信號、通路和轉(zhuǎn)運、細胞器標志物、熱休克、神經(jīng)生物學、神經(jīng)科學、氧化應激、磷酸化運輸?shù)取３颂峁┯糜谶M一步研究的相關工具外，Str