HSP110 belongs to a family of large stress proteins known as the HSP110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied HSP70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain (1). HSP110 cooperates with HSP70 in protein folding in the eukaryotic cytosol (2). In mammals, HSP110 is constitutively expressed, but exhibits particularly high levels in the brain. Both HSP70 and HSP110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of HSP110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of HSP70 (3). Studies also suggest that HSP110 can be used in heat shock protein-based cancer immunotherapy (4).
應(yīng)用類(lèi)型
WB | IHC | ICC/IF
免疫原
倉(cāng)鼠 Hsp110合成肽; 與人和小鼠序列相同
來(lái)源宿主
兔
反應(yīng)性
人 | 小鼠 | 大鼠 | 牛 | 猴 | 倉(cāng)鼠 | 綿羊 | 酵母菌 | 鯊
保存建議
廠家推薦藍(lán)冰運(yùn)輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專(zhuān)門(mén)從事試劑與試劑盒研究,服務(wù)范圍遍及3520多個(gè)國(guó)家。 StressMarq公司的核心技術(shù)領(lǐng)域?yàn)榧?xì)胞應(yīng)激(尤其是熱休克蛋白(HSP)領(lǐng)域,領(lǐng)先全球),離子通道,載體研究,同時(shí)在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到:細(xì)胞凋亡、細(xì)胞信號(hào)、通路和轉(zhuǎn)運(yùn)、細(xì)胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運(yùn)輸?shù)取3颂峁┯糜谶M(jìn)一步研究的相關(guān)工具外,Str