Biliverdin Reductase (BVR) is a cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin by converting a double bond between the second and third pyrrole ring into a single bond (1). It is ubiqutiously expressed in all tissues- it occurs in cells and brain regiuons that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. It is unique among all enzymes in having two pH optima, using a different cofactor at each pH range, NADH at pH7.0 and NADPH at pH8.7 (2). It is not inactivated by heat shock, and have shown to abate inflammation, oxidative stress and apoptosis (3).
應(yīng)用類型
WB | IHC | ICC/IF | IP
免疫原
人天然BVR全長蛋白
來源宿主
兔
反應(yīng)性
人
保存建議
廠家推薦藍(lán)冰運(yùn)輸。收到產(chǎn)品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞,是一家生物科技公司,專門從事試劑與試劑盒研究,服務(wù)范圍遍及3921多個(gè)國家。 StressMarq公司的核心技術(shù)領(lǐng)域?yàn)榧?xì)胞應(yīng)激(尤其是熱休克蛋白(HSP)領(lǐng)域,領(lǐng)先全球),離子通道,載體研究,同時(shí)在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到:細(xì)胞凋亡、細(xì)胞信號(hào)、通路和轉(zhuǎn)運(yùn)、細(xì)胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運(yùn)輸?shù)取3颂峁┯糜谶M(jìn)一步研究的相關(guān)工具外,Str