Abelson 蛋白酪氨酸激酶1抗體-Abl1 Antibody (pTyr226): Dylight 405代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: ABL1 is a widely-expressed, non-receptor protein-tyrosine kinase. It is stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. It is activated by autophosphorylation as well as by Src-family kinase-mediated phosphorylation. It can also be activated by RIN1 binding to the SH2 and SH3 domains. As it is stimulated by cell death inducers and DNA-damage, it is likely that the wild-type form of Abl1 is actually a tumour -suppressor protein. The normal active form of Abl1 is nuclear, and it is sequestered into the cytoplasm by interaction with 14-3-3 through Thr-735. It localizes to the mitochondria under conditions of oxidative stress.

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務(wù)范圍遍及8530多個(gè)國(guó)家。 StressMarq公司的核心技術(shù)領(lǐng)域?yàn)榧?xì)胞應(yīng)激（尤其是熱休克蛋白（HSP）領(lǐng)域，領(lǐng)先全球），離子通道，載體研究，同時(shí)在神經(jīng)科學(xué)領(lǐng)域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產(chǎn)品領(lǐng)域涉及到：細(xì)胞凋亡、細(xì)胞信號(hào)、通路和轉(zhuǎn)運(yùn)、細(xì)胞器標(biāo)志物、熱休克、神經(jīng)生物學(xué)、神經(jīng)科學(xué)、氧化應(yīng)激、磷酸化運(yùn)輸?shù)取３颂峁┯糜谶M(jìn)一步研究的相關(guān)工具外，Str