Anti-人CD20 PE-Cy 7(流式抗體)-Anti-Hu CD20 PE-Cy 7代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

PRODUCT CENTER

一抗

產(chǎn)品中心

當(dāng)前位置：首頁 > 產(chǎn)品中心 > 免疫學(xué)產(chǎn)品 > 一抗

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868。

背景資料: CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.

保存建議: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.

其他: EXBIO是捷克一家著名的生物試劑公司，專注于流式細(xì)胞術(shù)配套試劑的開發(fā)。自1990年成立以來，EXBIO公司研發(fā)和制造的抗體分銷全球。目前，EXBIO可提供超過4000種質(zhì)優(yōu)、價(jià)廉的研究和臨床應(yīng)用抗體，涵蓋了血液學(xué)，免疫學(xué)，癌癥，干細(xì)胞和細(xì)胞生物學(xué)等領(lǐng)域，如：CD分子、細(xì)胞粘附分子、細(xì)胞骨架、凋亡、細(xì)胞信號傳導(dǎo)、腫瘤標(biāo)志物、人血型、HLA、生殖等研究用抗體，涉及熒光染料如FITC、PE、PE-Cy5、PE-Cy7、APC、PerCP、PerCP-Cy5.5、Pacific Blue、Pacific Orange、Alexa Fluor 488、Alexa Fluor 647、Alexa Fluor 700、Biotin等多達(dá)13種，滿足客戶各類實(shí)驗(yàn)需求。